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Bsxtm2Aoh
Targeted Allele Detail
Nomenclature
Symbol: Bsxtm2Aoh
Name: brain specific homeobox; targeted mutation 2, Akihira Ohtoshi
MGI ID: MGI:3719245
Synonyms: BsxlacZ
Gene: Bsx  Location: Chr9:40874127-40878962 bp, + strand  Genetic Position: Chr9, 21.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123638
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTargeting took place in PC3 ES cells homozygous for the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. A targeting vector containing lacZ sequence and a floxed neo cassette was inserted by homologous recombination in ES cells. The neo cassette was subsequently removed upon transmission from male chimeric mice, resulting in the deletion of the homeodomain and expression of the lacZ reporter. Absence of endogenous transcript was confirmed by RT-PCR. (J:123638)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bsx Mutation:  13 strains or lines available
References
Original:  J:123638 McArthur T, et al., A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing. Mol Cell Biol. 2007 Jul;27(14):5120-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory