Eeq1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Eeq1^DBA/2J
• Name: exercise endurance QTL 1; DBA/2J
• MGI ID: MGI:3718665
• QTL: Eeq1 Location: unknown Genetic Position: ChrX, cM position of peak correlated region/allele: 73.95 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:123466

Genetic loci associated with exercise endurance were mapped in 99 animals from a (BALB/cJ x DBA/2J)F2 intercross. Parental strain BALB/cJ displays high maximum exercise endurance whereas parental strain DBA/2J displays low maximal exercise endurance. Animals were phenotyped on running wheels at 6- to 9-weeks of age. A panel of 108 polymorphic markers at a resolution of 12.6 cM was used for genome scan.

A locus at 59.6 cM on mouse Chromosome X shows linkage to exercise endurance near DXMit121 (LOD=2.45) in the initial genome scan using 24 animal with highest and lowest phenotypes. This locus was confirmed in fine map analysis (DXMit31, LOD=2.26) and is designated Eeq1 (exercise endurance QTL 1). Eeq1 explains 10% of the variance and appears to be orthologous to a rat exercise endurance QTL at D16Rat17.

Suggestive linkage to exercise endurance in females was detected at 42.1 cM on mouse Chromosome 8 near D8Mit359 (LOD=2.21). This locus was subsequently confirmed in fine map analysis and is designated Eeq2 (exercise endurance QTL 2). Eeq2 explains 9% of the variance.

References

• Original: J:123466 Lightfoot JT, et al., Quantitative trait loci associated with maximal exercise endurance in mice. J Appl Physiol. 2007 Jul;103(1):105-10
• All: 1 reference(s)