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Targeted Allele Detail
Symbol: Atg4ctm1Otin
Name: autophagy related 4C, cysteine peptidase; targeted mutation 1, Carlos Lopez-Otin
MGI ID: MGI:3718523
Synonyms: Atg4c-
Gene: Atg4c  Location: Chr4:99193934-99259787 bp, + strand  Genetic Position: Chr4, 45.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:123386
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA pgk-neo cassette replaced exons 1-4 of the locus, including sequences encoding the catalytic domain. RT-PCR confirmed absence of transcript in mutant brain, testis, liver and kidney samples. (J:123386)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atg4c Mutation:  22 strains or lines available
Original:  J:123386 Marino G, et al., Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem. 2007 Jun 22;282(25):18573-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory