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Targeted Allele Detail
Symbol: Ramp2tm1Kmca
Name: receptor (calcitonin) activity modifying protein 2; targeted mutation 1, Kathleen Caron
MGI ID: MGI:3718497
Synonyms: Ramp2-
Gene: Ramp2  Location: Chr11:101246028-101259546 bp, + strand  Genetic Position: Chr11, 64.47 cM
Developmental cardiovascular defects in Ramp2tm1Kmca/Ramp2tm1Kmca embryos

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:123382
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe promoter region and exons 1 and 2 were replaced with the neomycin resistance cassette. Quantitative RT-PCR did not detect transcripts in mutant embryonic RNA extracts. (J:123382)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ramp2 Mutation:  5 strains or lines available
Original:  J:123382 Dackor R, et al., Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age. J Biol Chem. 2007 Jun 22;282(25):18094-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory