Hdac2^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac2^tm1.1Eno
• Name: histone deacetylase 2; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3717927
• Synonyms: Hdac2^loxP
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123173
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced upstream of exon 2 and downstream of exon 4, flanking a portion of the oligomerization domain and residues in the catalytic domain required for enzymatic activity. A FRT-flanked neo was removed from the locus via Flp mediated recombination. (J:123173)

Expression

In Mice Carrying this Mutation:

8 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 38 strains or lines available

References

• Original: J:123173 Montgomery RL, et al., Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 2007 Jul 15;21(14):1790-802
• All: 33 reference(s)