About   Help   FAQ
Transgene Detail
Symbol: Tg(PDGFB-APPSwInd)J9Lms
Name: transgene insertion J9, Lennart Mucke
MGI ID: MGI:3717718
Synonyms: APPSw,Ind, hAPPJ9, Tg(PDGF-APP*Swe*Ind)J9Lms, Tg(PDGFB-APP*)J9Lms
Transgene: Tg(PDGFB-APPSwInd)J9Lms  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PDGFB-APPSwInd)J9Lms expresses 1 gene
Mutation detailsThe transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. The Swedish APP (K670N/M671L) mutation was introduced into the construct by PCR primer modification. The modified construct was microinjected into (C57BL/6 x DBA/2)F2 one-cell embryos. Mice show high levels of amyloid beta deposits in their hippocampi. (J:23080, J:100974)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:100974 Hsia AY, et al., Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3228-33
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory