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Tg(PDGFB-APPSwInd)J9Lms
Transgene Detail
Nomenclature
Symbol: Tg(PDGFB-APPSwInd)J9Lms
Name: transgene insertion J9, Lennart Mucke
MGI ID: MGI:3717718
Synonyms: APPSw,Ind, hAPPJ9, Tg(PDGFB-APP*)J9Lms
Transgene: Tg(PDGFB-APPSwInd)J9Lms  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PDGFB-APPSwInd)J9Lms expresses 1 gene
 
Mutation detailsThe transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. The Swedish APP (K670N/M671L) mutation was introduced into the construct by PCR primer modification. The modified construct was microinjected into (C57BL/6 x DBA/2)F2 one-cell embryos. Mice show high levels of amyloid beta deposits in their hippocampi. (J:23080, J:100974)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100974 Hsia AY, et al., Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3228-33
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory