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Tg(Gfap-TGFB1)64Lms
Transgene Detail
Nomenclature
Symbol: Tg(Gfap-TGFB1)64Lms
Name: transgene insertion 64, Lennart Mucke
MGI ID: MGI:3717676
Synonyms: GFAP/TGF-B1, pTGF-B1
Transgene: Tg(Gfap-TGFB1)64Lms  Location: unknown  
Transgene
origin
Strain of Origin:  (BALB/c x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Homozygous trangenic mice develop severe hydrocephalus within 7-20 days after birth and exhibit dwarfism relative to non-transgenic littermates. Mice develop seizures, tremors, incoordination, and hunched postures. Only 1% of heterozygotes developed hydrocephalus.

References
Original:  J:27781 Wyss-Coray T, et al., Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am J Pathol. 1995 Jul;147(1):53-67
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory