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Transgene Detail
Symbol: Tg(PDGFB-APPInd)H6Lms
Name: transgene insertion H6, Lennart Mucke
MGI ID: MGI:3717672
Synonyms: APPInd, PDGF-hAPP line 6, PDGF-hAPP line H6, Tg(PDGFB-APP*Ind)H6Lms, Tg(PDGFB-APP*V717F)H6Lms
Transgene: Tg(PDGFB-APPInd)H6Lms  Location: unknown  
Strain of Origin:  Not Applicable
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. Amyloid-beta ELISA on whole brain homogenates indicates higher cerebral beta-amyloid production than in Tg(APPV717F)109Ili mice expressing the same construct. (J:100980, J:102272)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:102272 Wyss-Coray T, et al., Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature. 1997 Oct 9;389(6651):603-6
All:  4 reference(s)

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