About   Help   FAQ
Transgene Detail
Symbol: Tg(Eno2-PTGS2)32Pasi
Name: transgene insertion 32, Guilio Maria Pasinetti
MGI ID: MGI:3717604
Synonyms: hCOX-2, hCOX-2 transgenic, NHC32
Transgene: Tg(Eno2-PTGS2)32Pasi  Location: unknown  
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Eno2-PTGS2)32Pasi expresses 1 gene
Mutation detailsThe 1950 bp cDNA for the entire coding region of human PTGS2 was inserted into the second exon of the rat neuron-specific enolase gene (Eno2). The construct also contains the polyadenylation signal from the SV40 late region. This construct was microinjected into one-cell B6C3F1 mouse oocytes. Transgene mRNA is expressed only in the brain as shown by Northern blot, and Western blot showed human PTGS2 protein expression in brain tissue homogenates. (J:100973)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:100973 Kelley KA, et al., Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol. 1999 Sep;155(3):995-1004
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.03
The Jackson Laboratory