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Gene trapped Allele Detail
Symbol: Tctn1Gt(KST296)Byg
Name: tectonic family member 1; gene trap KST296, BayGenomics
MGI ID: MGI:3716885
Gene: Tctn1  Location: Chr5:122239495-122264489 bp, - strand  Genetic Position: Chr5, 62.25 cM
Mutant Cell Line:  KST296
Germline Transmission:  Earliest citation of germline transmission: J:103820
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1TMpfs     Vector Type: secretory trap
Mutation detailsA gene trap vector inserted into intron 1, resulting in a mutant allele containing the first 57 amino acids and a membrane-spanning betageo reporter. Wild-type transcript was shown to be absent in mutants by RT-PCR and Northern blot analyses. (J:103820)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tctn1 Mutation:  19 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:103820 Reiter JF, et al., Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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