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Targeted Allele Detail
Symbol: Prex1tm1Dwu
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; targeted mutation 1, Dianqing Wu
MGI ID: MGI:3716869
Synonyms: P-Rex1-
Gene: Prex1  Location: Chr2:166566345-166713832 bp, - strand  Genetic Position: Chr2, 87.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:102213
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exon 4, encoding residues 135-169 with a neomycin resistance cassette. RT-PCR confirmed absence of wild-type transcript (J:102213)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prex1 Mutation:  40 strains or lines available
Original:  J:102213 Dong X, et al., P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol. 2005 Oct 25;15(20):1874-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory