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Prex1tm1Hcew
Targeted Allele Detail
Nomenclature
Symbol: Prex1tm1Hcew
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; targeted mutation 1, Heidi C E Welch
MGI ID: MGI:3716859
Synonyms: P-Rex1-
Gene: Prex1  Location: Chr2:166566345-166713832 bp, - strand  Genetic Position: Chr2, 87.09 cM
Limb clasping in Prex1tm1Hcew/Prex1tm1Hcew Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102214
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5, which encodes catalytic residues in the DH domain, was replaced with a neomycin resistance cassette and a translational stop codon. Northern blot confirmed absence of transcript in mutant mice. (J:102214)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prex1 Mutation:  42 strains or lines available
References
Original:  J:102214 Welch HC, et al., P-Rex1 regulates neutrophil function. Curr Biol. 2005 Oct 25;15(20):1867-73
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory