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Shc1tm5Paw
Targeted Allele Detail
Nomenclature
Symbol: Shc1tm5Paw
Name: src homology 2 domain-containing transforming protein C1; targeted mutation 5, Tony Pawson
MGI ID: MGI:3716779
Synonyms: ShcA2F
Gene: Shc1  Location: Chr3:89418443-89430015 bp, + strand  Genetic Position: Chr3, 39.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122927
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsA targeting vector was used to insert cDNA containing Y239/240F substitutions with a single Flag-pA epitope tag and a floxed neo into exon 3, replacing the exon 4 of the locus. (J:122927)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shc1 Mutation:  46 strains or lines available
References
Original:  J:122927 Hardy WR, et al., Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. 2007 Jul 13;317(5835):251-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory