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Targeted Allele Detail
Symbol: Hsd3b7tm1Rus
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; targeted mutation 1 David W Russell
MGI ID: MGI:3716711
Synonyms: Hsd3b7-
Gene: Hsd3b7  Location: Chr7:127399781-127402975 bp, + strand  Genetic Position: Chr7, 69.74 cM
Phenotypes of Hsd3b7tm1Rus/Hsd3b7tm1Rus mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:122973
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1-6 were replaced by the ACN cassette encoding neomycin resistance and cre recombinase. Passage through the germline resulted in the deletion of the cassette, leaving a single loxP site. Protein was not detected in immunoblot of mutants. (J:122973)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsd3b7 Mutation:  13 strains or lines available
ES cell line = I1C.
Original:  J:122973 Shea HC, et al., Inaugural Article: Analysis of HSD3B7 knockout mice reveals that a 3{alpha}-hydroxyl stereochemistry is required for bile acid function. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11526-33
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory