Pink1^tm1Shn
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Shn
• Name: PTEN induced putative kinase 1; targeted mutation 1, Jie Shen
• MGI ID: MGI:3716083
• Synonyms: Pink1^-
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Shn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122728
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-7 were replaced with a pgk-neo cassette via cre mediated recombination, thereby removing the majority of the kinase domain and creating a nonsense mutation at the beginning of exon 8. Northern blot confirmed absence of transcript in mutants. (J:122728)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 42 strains or lines available

References

• Original: J:122728 Kitada T, et al., From the Cover: Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6
• All: 43 reference(s)