About   Help   FAQ
Pink1tm1Shn
Targeted Allele Detail
Nomenclature
Symbol: Pink1tm1Shn
Name: PTEN induced putative kinase 1; targeted mutation 1, Jie Shen
MGI ID: MGI:3716083
Synonyms: Pink1-
Gene: Pink1  Location: Chr4:138313409-138326296 bp, - strand  Genetic Position: Chr4, 70.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122728
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4-7 were replaced with a pgk-neo cassette via cre mediated recombination, thereby removing the majority of the kinase domain and creating a nonsense mutation at the beginning of exon 8. Northern blot confirmed absence of transcript in mutants. (J:122728)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pink1 Mutation:  9 strains or lines available
References
Original:  J:122728 Kitada T, et al., From the Cover: Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory