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Targeted Allele Detail
Symbol: Pik3catm1Jdo
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Julian Downward
MGI ID: MGI:3716068
Synonyms: Pik3caRBD
Gene: Pik3ca  Location: Chr3:32397065-32466112 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:122866
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
Mutation detailsA targeting vector was designed to replace threonine 208 with aspartic acid (T208D) and lysine 227 with alanine (L227A) in exon 3. Cre-mediated recombination was used to remove a floxed neo from the locus. (J:122866)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  19 strains or lines available
Original:  J:122866 Gupta S, et al., Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell. 2007 Jun 1;129(5):957-68
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory