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Tg(Dvl2*K446M/EGFP)5Awb
Transgene Detail
Summary
Symbol: Tg(Dvl2*K446M/EGFP)5Awb
Name: transgene insertion 5, Anthony Wynshaw-Boris
MGI ID: MGI:3715920
Synonyms: dsh1-EGFP
Transgene: Tg(Dvl2*K446M/EGFP)5Awb  Location: unknown  
Alliance: Tg(Dvl2*K446M/EGFP)5Awb page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Dvl2*K446M/EGFP)5Awb expresses 1 gene
 
Mutation detailsThe Dvl2 promoter drives the expression of Dvl2 with EGFP fused downstream of the 15th exon with a LoxP site inserted 3' of Acadvl, and a point mutation introduced at the codon 446. This mutation is predicted to alter lysine 446 to methionine in the encoded protein. The point mutation is identical to a varaint identified in Drosophila that abolishes planar cell polarity function. (J:108512)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:108512 Wang J, et al., Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006 May;133(9):1767-78
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory