Mesp2^{tm13(cre/Esr1*)Ysa}
Targeted Allele Detail

Summary

• Symbol: Mesp2^{tm13(cre/Esr1*)Ysa}
• Name: mesoderm posterior 2; targeted mutation 13, Yumiko Saga
• MGI ID: MGI:3715268
• Synonyms: Mesp2^neo-MCM, Mesp2^{tm13(cre/Esr1)Ysa}
• Gene: Mesp2 Location: Chr7:79460475-79463179 bp, + strand Genetic Position: Chr7, 45.18 cM
• Alliance: Mesp2^{tm13(cre/Esr1*)Ysa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122532
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Mesp2^{tm13(cre/Esr1*)Ysa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mesp2 (MGI:1096325)

• Mutation details: A floxed-neo and cre recombinase/mutant estrogen receptor ligand binding domain fusion cassette replaces the entire open reading frame. However, no cre expression is detected. (J:122532)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mesp2 (mouse) Summary of all recombinase alleles driven by Mesp2. Alliance mouse Mesp2 gene page

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp2 Mutation: 30 strains or lines available

References

• Original: J:122532 Takahashi Y, et al., Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev Biol. 2007 Apr 15;304(2):593-603
• All: 2 reference(s)