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Targeted Allele Detail
Symbol: Gfra1tm2Jmi
Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 2, Jeffrey Milbrandt
MGI ID: MGI:3715156
Synonyms: Gfra1flox, Gfralpha1floxEGFP
Gene: Gfra1  Location: Chr19:58235604-58455909 bp, - strand  Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
Germline Transmission:  Earliest citation of germline transmission: J:122607
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed Gfra1 cDNA-SV40-polyA with a GFP-polyA and a FRTed Tn5 neo was introduced into exon 2, deleting 95 nucleotides containing the 5' UTR, the initiator Met and the signal sequences. Expression of the endogenous gene was abolished, however, the inserted gene was expressed. Crossing with mice expressing FLP recombinase removed the neo. (J:122607)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra1 Mutation:  5 strains or lines available
Original:  J:122607 Uesaka T, et al., Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development. 2007 Jun;134(11):2171-81
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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