Hprt1^{tm1(UBC-UBB)Rrk}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(UBC-UBB)Rrk}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Ron R Kopito
• MGI ID: MGI:3715138
• Synonyms: HA-Ub
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(UBC-UBB)Rrk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122574
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(UBC-UBB)Rrk} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ubb (MGI:98888)

• Mutation details: A tandem repeat of 6 hemagglutinin-tagged UBB open reading frames was placed under the control of the human UBC promoter and inserted into the Hprt locus. (J:122574)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1273 strains or lines available

References

• Original: J:122574 Ryu KY, et al., The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 2007 Jun 6;26(11):2693-706
• All: 3 reference(s)