Pcsk1^tm1Mbi
Targeted Allele Detail

Summary

• Symbol: Pcsk1^tm1Mbi
• Name: proprotein convertase subtilisin/kexin type 1; targeted mutation 1, Majambu Mbikay
• MGI ID: MGI:3714927
• Synonyms: Pcsk1^-
• Gene: Pcsk1 Location: Chr13:75237945-75282980 bp, + strand Genetic Position: Chr13, 40.63 cM, cytoband C2
• Alliance: Pcsk1^tm1Mbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122555
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 3-9 with a neomycin resistance cassette. RT-PCR revealed the presence of aberrant transcripts resulting from the fusion of the N-terminal half of the propeptide with the neo gene product. (J:122555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcsk1 Mutation: 50 strains or lines available

References

• Original: J:78623 Villeneuve P, et al., Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. J Neurochem. 2002 Aug;82(4):783-93
• All: 2 reference(s)