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Targeted Allele Detail
Symbol: Dp(16Lipi-Zbtb21)1Yey
Name: duplication, Chr 16, Y Eugene Yu 1
MGI ID: MGI:3714529
Synonyms: Dp(16)1Yey, Dp(16)1Yu, Dp(16D930038D03Tik-Zfp295)1Yey, Dp(16Lipi-Zfp295)1Yey, Dp1Yu, Ts1Yey
Gene: Dp(16Lipi-Zbtb21)1Yey  Location: unknown  Genetic Position: Chr16, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:121790
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutation:    Duplication
  Dp(16Lipi-Zbtb21)1Yey involves 37 genes/genome features (Dgcr14, Gsc2, AA914427 ...) View all
Mutation detailsA 22.9Mb region of chromosome 16 that is syntenic with human chromosome 21 was duplicated using a Cre/loxP-mediated recombination system. This region, thought to be involved in Down Syndrome, contains 113 orthologues including all markers between and including D930038D03Rik (Lipi) and Zfp295 (Zbtb21). (J:121790)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dp(16Lipi-Zbtb21)1Yey Mutation:  3 strains or lines available
Original:  J:121790 Li Z, et al., Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum Mol Genet. 2007 Jun 1;16(11):1359-66
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory