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Targeted Allele Detail
Symbol: Dp(16Lipi-Zbtb21)1Yey
Name: duplication, Chr 16, Y Eugene Yu 1
MGI ID: MGI:3714529
Synonyms: Dp(16)1Yey, Dp(16)1Yu, Dp(16D930038D03Tik-Zfp295)1Yey, Dp(16Lipi-Zfp295)1Yey, Dp1Yu, Ts1Yey
Gene: Dp(16Lipi-Zbtb21)1Yey  Location: unknown  Genetic Position: Chr16, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:121790
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Duplication
  Dp(16Lipi-Zbtb21)1Yey involves 37 genes/genome features (Dgcr14, Gsc2, AA914427 ...) View all
Mutation detailsA 22.9Mb region of chromosome 16 that is syntenic with human chromosome 21 was duplicated using a Cre/loxP-mediated recombination system. This region, thought to be involved in Down Syndrome, contains 113 orthologues including all markers between and including D930038D03Rik (Lipi) and Zfp295 (Zbtb21). (J:121790)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dp(16Lipi-Zbtb21)1Yey Mutation:  3 strains or lines available
Original:  J:121790 Li Z, et al., Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum Mol Genet. 2007 Jun 1;16(11):1359-66
All:  21 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory