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Stx16tm1Hju
Targeted Allele Detail
Nomenclature
Symbol: Stx16tm1Hju
Name: syntaxin 16; targeted mutation 1, Harald Juppner
MGI ID: MGI:3714383
Synonyms: Stx16delta4-6
Gene: Stx16  Location: Chr2:174076308-174099771 bp, + strand  Genetic Position: Chr2, 97.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122325
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe vector contained a self-splicing floxed ACN cassette containing a neo and a cre recombinase gene and was inserted to replace exons 4-6. The final allele contains a sinlge loxP site in place of the exons as the neo and cre were deleted upon passage through the male germline. RT-PCR confirmed successful recombination of the locus in mutant kidney samples. (J:122325)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stx16 Mutation:  7 strains or lines available
References
Original:  J:122325 Frohlich LF, et al., Lack of Gnas epigenetic changes and pseudohypoparathyroidism type Ib in mice with targeted disruption of syntaxin-16. Endocrinology. 2007 Jun;148(6):2925-35
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory