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Mllt1tm1Dw
Targeted Allele Detail
Nomenclature
Symbol: Mllt1tm1Dw
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; targeted mutation 1, Dennis Willerford
MGI ID: MGI:3714136
Gene: Mllt1  Location: Chr17:56892611-56935415 bp, - strand  Genetic Position: Chr17, 29.56 cM, cytoband E1.1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108588
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into exon 6 results in a stop codon and is predicted to code for a truncated protein of less than 40% of mature size. (J:108588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mllt1 Mutation:  3 strains or lines available
Notes
ES cell line = GS (Genome Systems; 129/Sv).
References
Original:  J:108588 Doty RT, et al., The leukemia-associated gene Mllt1/ENL: characterization of a murine homolog and demonstration of an essential role in embryonic development. Blood Cells Mol Dis. 2002 May-Jun;28(3):407-17
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory