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Alkbh2tm1Klng
Targeted Allele Detail
Nomenclature
Symbol: Alkbh2tm1Klng
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Arne Klungland
MGI ID: MGI:3714064
Synonyms: mABH2 KO
Gene: Alkbh2  Location: Chr5:114123926-114128218 bp, - strand  Genetic Position: Chr5, 55.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108782
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 3.2kb of sequence including all of exon 4. The deleted region contains the conserved 2-oxoglutarate- and Fe(II)-dependent oxygenase domain and the AlkB domain. (J:108782)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alkbh2 Mutation:  70 strains or lines available
References
Original:  J:108782 Ringvoll J, et al., Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J. 2006 May 17;25(10):2189-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory