Bmp4^tm1Jlch
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm1Jlch
• Name: bone morphogenetic protein 4; targeted mutation 1, Jan L Christian
• MGI ID: MGI:3714056
• Synonyms: Bmp4^S2Gneo
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm1Jlch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108516
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette introduced two point mutations into exon 4 and placed a neomycin selectable marker flanked by loxP sites downstream of exon 4. The S2G mutation causes a single amino acid change predicted to prevent cleavage of the S2 site of the protein, and a silent point mutation that codes for a PvuI site in place of a BglII site. (J:108516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 21 strains or lines available

References

• Original: J:108516 Goldman DC, et al., Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development. 2006 May;133(10):1933-42
• All: 1 reference(s)