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Leprtm2Mgmj
Targeted Allele Detail
Nomenclature
Symbol: Leprtm2Mgmj
Name: leptin receptor; targeted mutation 2, Martin G Myers, Jr
MGI ID: MGI:3713767
Synonyms: LeprL985, LeprLeu985
Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122056
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsTyr985 was converted to a leucine in exon 18b abrogating a phosphorylation site. A Southern blot was used to confirm the conversion. (J:122056)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  90 strains or lines available
References
Original:  J:122056 Bjornholm M, et al., Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest. 2007 May;117(5):1354-60
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory