Grid1^tm1Jnz
Targeted Allele Detail

Summary

• Symbol: Grid1^tm1Jnz
• Name: glutamate receptor, ionotropic, delta 1; targeted mutation 1, Jian Zuo
• MGI ID: MGI:3712980
• Synonyms: GluRdelta1^-
• Gene: Grid1 Location: Chr14:34542065-35305336 bp, + strand Genetic Position: Chr14, 20.84 cM
• Alliance: Grid1^tm1Jnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121999
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 11 and 12, containing transmembranes 1, 2 and 3, were replaced with a neomycin resistance cassette. The targeting event introduced a frameshift after exon 12. Western blot confirmed absence of protein in mutant inner ear, hippocampal, and cerebellar homogenates. (J:121999)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grid1 Mutation: 59 strains or lines available

References

• Original: J:121999 Gao J, et al., Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol. 2007 Jun;27(12):4500-12
• All: 8 reference(s)