About   Help   FAQ
Hspg2tm1Rdgr
Targeted Allele Detail
Summary
Symbol: Hspg2tm1Rdgr
Name: perlecan (heparan sulfate proteoglycan 2); targeted mutation 1, Kathryn D Rodgers
MGI ID: MGI:3712962
Synonyms: C1532Yneo
Gene: Hspg2  Location: Chr4:137196080-137297941 bp, + strand  Genetic Position: Chr4, 69.93 cM
Alliance: Hspg2tm1Rdgr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121855
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    A G4595A mutation was introduced into exon 36. The construct included an frt-flanked neo cassette. (J:121855)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspg2 Mutation:  308 strains or lines available
References
Original:  J:121855 Rodgers KD, et al., Reduced perlecan in mice results in chondrodysplasia resembling Schwartz-Jampel syndrome. Hum Mol Genet. 2007 Mar 1;16(5):515-28
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory