Tg(Cyp19a1-cre)5912Gle
Transgene Detail

Summary

• Symbol: Tg(Cyp19a1-cre)5912Gle
• Name: transgene insertion 5912, Gustavo Leone
• MGI ID: MGI:3712298
• Synonyms: CYP19-Cre
• Transgene: Tg(Cyp19a1-cre)5912Gle Location: unknown
• Alliance: Tg(Cyp19a1-cre)5912Gle page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cyp19a1-cre)5912Gle expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cyp19a1

• Mutation details: This transgene uses the cytochrome P450, family 19, subfamily a, polypeptide 1 promoter to drive expression of cre recombinase in the placenta. The transgene also contains an IRES-luciferase, the rabbit beta-globin intron and the SV-40 polyA signal. When crossed to R26R reporter mice, the 5912 founder line exhibited cre activity throughout the spongiotrophoblast and labyrinth trophoblast of E13.5 placentas (only a small percentage of fetuses display X-gal in the internal organs.) The transgene is active by E6.5 in early diploid trophoblast cells having initiated commitment to a differentiated state but is inactive in early, undifferentiated trophoblast stem cells. Strength of cre expression was related to parental inheritance, with maternal inheritance providing the strongest, most consistent placental expression. This line was studied in detail. (J:121714)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp19a1 (species not specified) Summary of all recombinase alleles driven by Cyp19a1. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

24 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:121714 Wenzel PL, et al., Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta. Genesis. 2007 Mar;45(3):129-34
• All: 23 reference(s)