Hdac2^{Gt(W035F03)Joe}
Gene trapped Allele Detail

Summary

• Symbol: Hdac2^{Gt(W035F03)Joe}
• Name: histone deacetylase 2; gene trap W035F03, Jonathan A Epstein
• MGI ID: MGI:3712002
• Synonyms: Hdac2^-
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^{Gt(W035F03)Joe} page

Mutation origin

• Mutant Cell Line: W035F03
• Germline Transmission: Earliest citation of germline transmission: J:121697
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pT1betageo
• Mutation details: A gene trap containing lacZ was inserted into intron 8 and removed exons 9-14, which encode portions of the catalyitic domain. Western blot demonstrated absence of protein from mutant embryos. (J:121697)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  W035F03	ET639096 ; (MGI Seq Detail)	5' RACE	multiple
  * GRCm39; (strand of gene trap mutagenesis)

Expression

In Mice Carrying this Mutation:	27 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 38 strains or lines available

References

• Original: J:121697 Trivedi CM, et al., Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31
• All: 7 reference(s)