Gnai2^tm1.1Rneu
Targeted Allele Detail

Summary

• Symbol: Gnai2^tm1.1Rneu
• Name: G protein subunit alpha i2; targeted mutation 1.1, Richard R Neubig
• MGI ID: MGI:3711989
• Synonyms: Galphai2^G184S, Galphai2^GS
• Gene: Gnai2 Location: Chr9:107491324-107512542 bp, - strand Genetic Position: Chr9, 58.43 cM
• Alliance: Gnai2^tm1.1Rneu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121385
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Cre mediated recombination resulted in the loss of the floxed neo from Gnai2^tm1Rneu, leaving a glycine to serine substitution G184S in exon 5. (J:121385)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnai2 Mutation: 54 strains or lines available

References

• Original: J:121385 Fu Y, et al., Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res. 2006 Mar 17;98(5):659-66
• All: 17 reference(s)