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Gnai2tm1.1Rneu
Targeted Allele Detail
Nomenclature
Symbol: Gnai2tm1.1Rneu
Name: guanine nucleotide binding protein (G protein), alpha inhibiting 2; targeted mutation 1.1, Richard R Neubig
MGI ID: MGI:3711989
Synonyms: Galphai2G184S, Galphai2GS
Gene: Gnai2  Location: Chr9:107491324-107512566 bp, - strand  Genetic Position: Chr9, 58.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121385
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsCre mediated recombination resulted in the loss of the floxed neo from Gnai2tm1Rneu, leaving a glycine to serine substitution G184S in exon 5. (J:121385)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gnai2 Mutation:  50 strains or lines available
References
Original:  J:121385 Fu Y, et al., Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res. 2006 Mar 17;98(5):659-66
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory