Col17a1^tm1Shzu
Targeted Allele Detail

Summary

• Symbol: Col17a1^tm1Shzu
• Name: collagen, type XVII, alpha 1; targeted mutation 1, Hiroshi Shimizu
• MGI ID: MGI:3711776
• Synonyms: Col17^m-
• Gene: Col17a1 Location: Chr19:47634783-47680460 bp, - strand Genetic Position: Chr19, 40.07 cM
• Alliance: Col17a1^tm1Shzu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a PGK-neo cassette by homologous recombination. Northern blot confirmed absence of transcript in mutant karatinocytes, and Western blot confirmed absence of protein. (J:121695)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col17a1 Mutation: 49 strains or lines available

References

• Original: J:121695 Nishie W, et al., Humanization of autoantigen. Nat Med. 2007 Mar;13(3):378-83
• All: 11 reference(s)