Pygo2^tm1.1Xdai
Targeted Allele Detail

Summary

• Symbol: Pygo2^tm1.1Xdai
• Name: pygopus 2; targeted mutation 1.1, Xing Dai
• MGI ID: MGI:3711738
• Synonyms: f pygo2
• Gene: Pygo2 Location: Chr3:89337521-89342435 bp, + strand Genetic Position: Chr3, 39.12 cM
• Alliance: Pygo2^tm1.1Xdai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121776
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 3, which encodes amino acids 52-405 of the protein, including a conserved PHD finger domain. (J:121776)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pygo2 Mutation: 24 strains or lines available

References

• Original: J:121776 Li B, et al., Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May;45(5):318-25
• All: 8 reference(s)