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Akap6tm1Jsco
Targeted Allele Detail
Nomenclature
Symbol: Akap6tm1Jsco
Name: A kinase (PRKA) anchor protein 6; targeted mutation 1, John D Scott
MGI ID: MGI:3711141
Synonyms: mAKAP alpha-
Gene: Akap6  Location: Chr12:52699383-53155599 bp, + strand  Genetic Position: Chr12, 22.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121227
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 2 with an IRES, LacZ, URA and neomycin cassette and thus inhibit the production of the alpha alternative transcript. (J:121227)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Akap6 Mutation:  64 strains or lines available
References
Original:  J:121227 Michel JJ, et al., Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell. 2005 Dec 9;20(5):661-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory