Col1a2^tm1.1Mcbr
Targeted Allele Detail

Summary

• Symbol: Col1a2^tm1.1Mcbr
• Name: collagen, type I, alpha 2; targeted mutation 1.1, Daniel J McBride
• MGI ID: MGI:3711122
• Synonyms: G610C Neo-, G610C OI (Amish)
• Gene: Col1a2 Location: Chr6:4505618-4541543 bp, + strand Genetic Position: Chr6, 1.81 cM
• Alliance: Col1a2^tm1.1Mcbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121691
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted upstream of exon 35 and a G to T mutation was inserted in exon 35 resulting in a glycine to cysteine mutation at codon 706. Cre mediated recombination removed the neo cassette. (J:121691)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a2 Mutation: 119 strains or lines available

References

• Original: J:121691 McBride DJ, A knock-in mutation of Col1a2. MGI Direct Data Submission. 2007
• All: 10 reference(s)