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Dnmt3atm1Jae
Targeted Allele Detail
Nomenclature
Symbol: Dnmt3atm1Jae
Name: DNA methyltransferase 3A; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:3711072
Synonyms: Dnmt3a2lox, Dnmt3aF
Gene: Dnmt3a  Location: Chr12:3806007-3914443 bp, + strand  Genetic Position: Chr12, 1.99 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121563
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neomycin resistance gene was inserted into intron 17 and loxP sites were inserted into introns 17 and 20. The neo was removed via translient flp recombinase expression. (J:121563)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnmt3a Mutation:  89 strains or lines available
References
Original:  J:121563 Nguyen S, et al., Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan. Dev Dyn. 2007 Jun;236(6):1663-76
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory