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Tg(HLA-A/H2-D/B2M)1Dvs
Transgene Detail
Nomenclature
Symbol: Tg(HLA-A/H2-D/B2M)1Dvs
Name: transgene insertion 1, David Serreze
MGI ID: MGI:3711057
Synonyms: HDD, HHD
Transgene: Tg(HLA-A/H2-D/B2M)1Dvs  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/ShiLtDvs
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(HLA-A/H2-D/B2M)1Dvs expresses 1 gene
 
Mutation detailsThis transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db. The construct was injected into fertilized NOD/ShiLtDvs oocytes. The construct was originally described in J:41077 and used to create a different transgenic line. (J:41077, J:121685)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Notes
The HDD construct was created and used to generate a differnet transgenic mouse line in J:41077.

References
Original:  J:121685 Takaki T, et al., HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol. 2006 Mar 1;176(5):3257-65
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory