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Targeted Allele Detail
Symbol: Bicc1tm1Emdr
Name: BicC family RNA binding protein 1; targeted mutation 1, E M de Robertis
MGI ID: MGI:3711021
Synonyms: BicC
Gene: Bicc1  Location: Chr10:70922832-71159700 bp, - strand  Genetic Position: Chr10, 36.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:121683
Parent Cell Line:  LW1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was used to place an in-frame LacZ reporter gene in the first exon of the gene at the initiator methionine and insert a neomycin resistance cassette downstream of the LacZ cassette downstream of exon 8. LacZ expression was observed in the Henson's node at embryonic day 7.5 and in the endoderm of the gut at embryonic day 8.5 (J:121683)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bicc1 Mutation:  19 strains or lines available
Original:  J:121683 de Robertis EM, A targeted mutation of Bicc1. MGI Direct Data Submission. 2007;
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory