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Transgene Detail
Symbol: Tg(Prnp-ITM2B/APP695*40)1Emcg
Name: transgene insertion 1, Eileen McGowan
MGI ID: MGI:3710691
Synonyms: BRI-Abeta1-40, BRI-Abeta40
Transgene: Tg(Prnp-ITM2B/APP695*40)1Emcg  Location: unknown  
Strain of Origin:  (C3H x C57BL/6)F1 x C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe BRI-Abeta40 transgene was generated with a mouse prion promoter upstream of a BRI-Abeta40 fusion construct, containing a cDNA sequence from human type 2 transmembrane protein (BRI or ITM2B) fused in-frame with a "wildtype APP695" cDNA sequence encoding amyloid-beta40 (Abeta40) at the furin-like cleavage site; the C-terminal 23 amino acid ABri peptide of BRI was replaced with the Abeta40 sequence. A single founder line with the highest Abeta40 plasma levels (line 1d) was donated to The Jackson Laboratory. Transgenic fusion protein expression approximates levels of endogenous mouse APP expression and is expressed in patterns characteristic of the Prnp promoter, with highest expression in cerebellar granule cells and hippocampus. Full length Abeta fusion protein is most highly expressed with processed Abeta40 peptide expressed at lower levels. (J:101023)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:101023 McGowan E, et al., Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 2005 Jul 21;47(2):191-9
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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