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Targeted Allele Detail
Symbol: Spentm2.1Hon
Name: spen family transcription repressor; targeted mutation 2.1, Tasuku Honjo
MGI ID: MGI:3710413
Synonyms: MINT cko, Mintf
Gene: Spen  Location: Chr4:141467890-141538597 bp, - strand  Genetic Position: Chr4, 74.26 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:121523
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsES cells containing the Spentm2Hon allele were infected with adenovirus expressing cre at low levels. This resulted in removal of the neomycin expression vector and left exon 11 flanked by loxP sites. (J:121523)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Spen Mutation:  88 strains or lines available
Original:  J:121523 Yabe D, et al., Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP. Genesis. 2007 May;45(5):300-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory