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Epas1tm1.1Mcs
Targeted Allele Detail
Nomenclature
Symbol: Epas1tm1.1Mcs
Name: endothelial PAS domain protein 1; targeted mutation 1.1, M Celeste Simon
MGI ID: MGI:3710344
Synonyms: Hif-2adelta
Gene: Epas1  Location: Chr17:86753907-86833410 bp, + strand  Genetic Position: Chr17, 56.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119731
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 2 was deleted by a recombination event when 3LoxP founders were crossed to Tg(EIIa-cre)C5379 mice to remove the floxed Neo cassette during creation of the floxed (tm1Mcs) allele. (J:119731)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:  21 strains or lines available
References
Original:  J:119731 Gruber M, et al., Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2301-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory