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Sptbn4tm1Mkom
Targeted Allele Detail
Nomenclature
Symbol: Sptbn4tm1Mkom
Name: spectrin beta, non-erythrocytic 4; targeted mutation 1, Masayuki Komada
MGI ID: MGI:3710201
Synonyms: sigma 1-
Gene: Sptbn4  Location: Chr7:27356383-27447686 bp, - strand  Genetic Position: Chr7, 15.88 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120916
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sigma 1-specific targeting vector was designed to replace exon 1 and part of exon 2 with a neomycin resistance cassette in reverse orientation. Immunoblot confirmed the absence of the sigma 1 isoform, and the normal expression of the sigma 6 isoform. (J:120916)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sptbn4 Mutation:  49 strains or lines available
References
Original:  J:120916 Uemoto Y, et al., Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of ranvier. J Biol Chem. 2007 Mar 2;282(9):6548-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory