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Rhotm1Shda
Targeted Allele Detail
Summary
Symbol: Rhotm1Shda
Name: rhodopsin; targeted mutation 1, Yoshinori Shichida
MGI ID: MGI:3710193
Synonyms: E112Q
Gene: Rho  Location: Chr6:115908709-115916997 bp, + strand  Genetic Position: Chr6, 53.72 cM
Alliance: Rhotm1Shda page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120882
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified isoform(s))
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting vector was designed to replace glutamate 122 with glutamine (E122Q) in exon 2, and to add a neomycin resistance gene into intron 1 in reverse direction. (J:120882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rho Mutation:  47 strains or lines available
References
Original:  J:120882 Imai H, et al., Molecular properties of rhodopsin and rod function. J Biol Chem. 2007 Mar 2;282(9):6677-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory