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Targeted Allele Detail
Symbol: Slc4a4tm1Ges
Name: solute carrier family 4 (anion exchanger), member 4; targeted mutation 1, Gary E Shull
MGI ID: MGI:3710188
Synonyms: Nbc1-, NBCe1-
Gene: Slc4a4  Location: Chr5:88886818-89239653 bp, + strand  Genetic Position: Chr5, 44.1 cM, cytoband E2
Follicular organization of the spleen is disrupted in Slc4a4tm1Ges/Slc4a4tm1Ges mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:120867
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 9 was replaced with a neomycin resistance gene. Absence of transcript was confirmed by Northern blot of mutant kidney, small intestine and colon. (J:120867)
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc4a4 Mutation:  7 strains or lines available
Original:  J:120867 Gawenis LR, et al., Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter. J Biol Chem. 2007 Mar 23;282(12):9042-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory