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Del(12Bdkrb2-Bdkrb1)1Mki
Targeted Allele Detail
Nomenclature
Symbol: Del(12Bdkrb2-Bdkrb1)1Mki
Name: deletion, Chr 12, Masao Kakoki 1; deletion, Chr12, Masao Kakoki 1
MGI ID: MGI:3710158
Synonyms: B1RB2R-null, Bdkrb1-/Bdkrb2-, Bdkrb2/Bdkrb1tm1Mki
Gene: Del(12Bdkrb2-Bdkrb1)1Mki  Location: unknown  Genetic Position: Chr12, Syntenic
Histological changes in the postischemic kidneys of wild type, Bdkrb2tm1Jfh/Bdkrb2tm1Jfh and MGI:3710159/MGI:3710159 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121339
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Del(12Bdkrb2-Bdkrb1)1Mki involves 2 genes/genome features (Bdkrb2, Bdkrb1) View all
 
Mutation detailsA targeting vector was designed to replace bradykinin receptor, beta 2 exon 3 and the bradykinin receptor, beta 1 exon with a floxed neomycin resistance cassette. (J:121339)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(12Bdkrb2-Bdkrb1)1Mki Mutation:  1 strain or line available
References
Original:  J:121339 Kakoki M, et al., Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7576-81
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory