Fh1^tm1Pjp
Targeted Allele Detail

Summary

• Symbol: Fh1^tm1Pjp
• Name: fumarate hydratase 1; targeted mutation 1, Patrick J Pollard
• MGI ID: MGI:3710112
• Synonyms: Fh1^fl
• Gene: Fh1 Location: Chr1:175428944-175453201 bp, - strand Genetic Position: Chr1, 81.58 cM
• Alliance: Fh1^tm1Pjp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exons 2 and 3 with loxP sites. An frt flanked neo was inserted downstream of the intron 3 loxP site. (J:120969)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fh1 Mutation: 35 strains or lines available

References

• Original: J:120969 Pollard PJ, et al., Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell. 2007 Apr;11(4):311-9
• All: 10 reference(s)