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Gene trapped Allele Detail
Symbol: Fkbp5Gt(RRC236)Byg
Name: FK506 binding protein 5; gene trap RRC236, BayGenomics
MGI ID: MGI:3710108
Synonyms: Fkbp51-
Gene: Fkbp5  Location: Chr17:28399095-28517524 bp, - strand  Genetic Position: Chr17, 14.66 cM
Mutant Cell Line:  RRC236 (BayGenomics)
Germline Transmission:  Earliest citation of germline transmission: J:120960
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
Mutation detailsThe pGT1Lxf gene trap vector that contains a splice acceptor and beta-geo was inserted into intron 4. Northern blot, quantitative RT-PCR and Western blot confirmed the expression of a fusion transcript and protein that lacked the peptidyl-prolyl cis/trans-isomerase-like domain and all three TPR domains critical for the protein's function. (J:120960)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
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View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp5 Mutation:  150 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

Original:  J:120960 Yong W, et al., Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem. 2007 Feb 16;282(7):5026-36
All:  2 reference(s)

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MGI 6.03
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