Myf5^tm1(cre)Mrc
Targeted Allele Detail

Summary

• Symbol: Myf5^tm1(cre)Mrc
• Name: myogenic factor 5; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:3710099
• Synonyms: Myf5^cre, Myf5-cre, Myf5^CreCAP, Myf5^Cre-Ke, Myf5-ICN^-
• Gene: Myf5 Location: Chr10:107318769-107321995 bp, - strand Genetic Position: Chr10, 55.95 cM
• Alliance: Myf5^tm1(cre)Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120967
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Recombinase)
• Mutation: Insertion
• Myf5^tm1(cre)Mrc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myf5 (MGI:97252)

• Mutation details: Cre is expressed as a second cistron from an IRES placed in the 3' UTR of the locus. An frt-flanked neo was inserted downstream of the cre recombinase. Reduced transcript expression was confirmed by semi-quantitative RT-PCR at E12.5. This allele is a hypomorph. (J:120967)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myf5 (mouse) Summary of all recombinase alleles driven by Myf5. Comparative matrix view of recombinase activities Alliance mouse Myf5 gene page

Disease models

Expression

In Mice Carrying this Mutation:

110 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Myf5^tm1(cre)Mrc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myf5 Mutation: 17 strains or lines available

References

• Original: J:120967 Haldar M, et al., A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell. 2007 Apr;11(4):375-88
• All: 26 reference(s)